Thursday, 10 October 2002

10:00 - 15:00 Registration

10:00 - 13:30 Open ISGO Structural Genomics Task Force Meetings (Chair: Tom Terwilliger)

10:00 - 10:15
Udo Heinemann (Berlin, Germany)
Brief introduction into structural genomics, the ISGO, and the structural genomics task forces

10:15 - 10:30
Tom Terwilliger (Los Alamos, NM, USA)
Task force on numerical criteria for evaluating and assuring structure quality

10:30 - 10:45
Steve Bryant (Bethesda, MD, USA)
Task force on tracking and registration of targets

10:45 - 11:00
Helen Berman (Piscataway, NJ, USA)
Task force on deposition, archiving, and curation of the primary information

11:00 - 11:15
Guy Dodson (York, UK)
Task force on mechanisms for publication and recording of methods

11:15 - 11:35 Break

11:35 - 11:50
Barbara Skene (London, UK) and John Norvell (Bethesda, MD, USA)
Task force on intellectual property and data release

11:50 - 12:35
Lawrence Sung (Baltimore, MD, USA)
Impact of patent rights on the dissemination and use of structural genomic data

12:35 - 13:30
Open discussion about ISGO and ISGO task forces

15:00 - 15:20 Welcome

Representatives of the Max Delbrück Center for Molecular Medicine,
the Berlin Senate,
the Federal Ministry for Education and Research,
and the International Structural Genomics Organisation (ISGO)

15:20 - 16:20 Opening Lecture (Chair: Udo Heinemann)

Robert Huber (Martinsried, Germany)
Molecular machines for protein degradation

16:20 - 17:00 Plenary Lecture (Chair: Dave Stuart)

Chris Dobson (Cambridge, UK)
Protein folding and its links to the evolution of protein structure

17:00 - 18:00 Protein Production for Structural Genomics (Chair: Shigeyuki Yokoyama)

17:00 - 17:20
Dave Stuart (Oxford, UK)
Piecing together the Oxford pipeline

17:20 - 17:40
Naomi Chayen (London, UK)
Tackling the bottleneck of protein crystallization for structural genomics

17:40 - 17:50
Takanori Kigawa (Yokohama, Japan)
High-throughput screening of proteins suitable for structure determination: Overview

17:50 - 18:00
Geoffrey S. Waldo (Los Alamos, NM, USA
Engineering proteins for high-throughput structural genomics

18:00 - 21:00 Welcome Mixer and Poster Session I (Including Mega Posters)

19:00 - 19:30
Karsten K. Panzer (PerZan)
Finissage zur Ausstellung & Projekt CROSSING OVER (Foyer MDC.C)

09:00 - 09:40 Plenary Lecture (Chair: Hartmut Oschkinat)

Kurt Wüthrich (Zürich/San Diego)
NMR in structural and functional genomics

09:40 - 10:40 Membrane Proteins (Chair: Kurt Wüthrich)

09:40 - 10:00
Lars-Oliver Essen (Marburg, Germany)
Halorhodopsin: Light-driven ion pumping made simple?

10:00 - 10:20
Timothy A. Cross (Tallahassee, FL, USA)
Integral membrane proteins structural genomics: Mycobacterium tuberculosis

10:20 - 10:40
César Fernández Estrabao (Zürich, Switzerland)
Solution NMR structure of the E. coli outer membrane protein OmpX

10:40 - 11:10 Coffee Break

11:10 - 11:50 Plenary Lecture (Chair: Ivano Bertini)

Chris Sander (Cambridge, USA)
The challenge of structural genomics

11:50 - 12:50 Structural Genomics and Disease (Chair: Ian A. Wilson)

11:50 - 12:10
Wim Hol (Seattle, WA, USA)
Medicinal protein crystallography and structural genomics for tropical diseases

12:10 - 12:30
Duncan McRee (San Diego, CA, USA)
A high-throughput protein crystallography pipeline for structure-based drug design

12:30 - 12:50
Ditlev Brodersen (Cambridge, UK)
Binding of antibiotics to the 30S ribosomal subunit

12:50 - 15:00 Lunch Break and Poster Session I (Including Mega Posters)

13:30 - 14:40 Perspectives for Structural Genomics in Europe (Room: Dendrite II/III) (Chair: Udo Heinemann)

13:30 - 13:50
Dave Stuart (Oxford, UK)
Structural genomics in Europe: Slow start, strong finish?

13:50 - 14:10
Josefina Enfedaque (European Commission, Brussels)
Structuring European research in structural genomics

14:10 - 14:40
Open discussion

15:00 - 15:40 Plenary Lecture(Chair: Sung-Hou Kim)

Dino Moras (Illkirch, France)
Ligand binding to nuclear hormone receptors

15:40 - 16:20 Biological Insight from Large Sets of Protein Structures (Chair: Sung-Hou Kim)

15:40 - 16:00
Sarah Teichmann (Cambridge, UK)
Domain duplications and combinations in Escherichia coli metabolic enzymes

16:00 - 16:20
Jeff Bonanno (New York, NY, USA)
The GHMP kinase superfamily: Evolutionary and mechanistic implications arising from structural studies

16:20 - 16:50 Coffee Break

16:50 - 17:50 Verified Hypotheses from Protein Structures (Chair: Andrzej Joachimiak)

16:50 - 17:10
Sung-Hou Kim (Berkeley, CA, USA)
Molecular functions of "hypothetical proteins" inferrable by their structures

17:10 - 17:30
Aled Edwards (Toronto, Canada)
Biochemical validation of structural hypotheses

17:30 - 17:50
Hartmut Oschkinat (Berlin, Germany)
Hypotheses about activities and functions of non-catalytic protein domains from NMR investigations

17:50 - 19:10 NMR Methods for Structural Genomics (Chair: Cheryl H. Arrowsmith)

17:50 - 18:10
Miguel Llinás (Pittsburgh, PA, USA)
Is it NMR or is it crystallography? CLOUDS, a direct method for protein structure elucidation via NMR proton densities.

18:10 - 18:30
Gaetano Montelione (Piscataway, NJ, USA)
Automated analysis of protein NMR assignments and structures

18:30 - 18:50
P. Güntert (Yokohama, Japan)
Automated NMR structure calculation with the new software CYANA

18:50 - 19:10
Michael A. Kennedy (Richland, WA, USA)
NMR-based structural genomics at the Pacific Northwest National Laboratory, USA

20:00 Speakers' Dinner(by invitation)

09:00 - 09:40 Plenary Lecture (Chair: Samar S. Hasnain)

Janet L. Thornton (London, UK)
From protein structure to biological function

09:40 - 10:40 Bioinformatics: Protein Space (Chair: Chris Sander)

09:40 - 10:00
Nicholas O'Toole (Montreal, Canada)
Analysis of worldwide structural genomics targets

10:00 - 10:20
Sung-Hou Kim (Berkeley, CA, USA)
A global view of the protein fold space

10:20 - 10:40
Liisa Holm (Helsinki, Finland)
More for less in structural genomics

10:40 - 11:10 Coffee Break

11:10 - 12:10 Functional Genomics (Chair: Gaetano T. Montelione)

11:10 - 11:30
Marc Vidal (Cambridge, MA, USA)
Toward a proteome atlas for C. elegans

11:30 - 11:50
Stefan Wiemann (Heidelberg, Germany)
Large-scale subcellular localisation and functional analysis of novel proteins <

11:50 - 12:10
Steven Brenner (Berkeley, CA, USA)
Alternative splicing, protein structure, and gene regulation

12:10 - 13:10 Hot Topics (Chair: B.C. Wang)

12:10 - 12:30
Gu Xiaocheng (Beijing, China) with Shi Yunyu, Liwen Niu, Zihe Rao, and Hai Pang
Structural genomics effort in China

12:30 - 12:50
Bill Studier (Brookhaven, NY, USA)
Protein production with inducible T7 expression systems

12:50 - 13:10
AllampuraM. Babu (Berlin, Germany)
Design of web book to handle meta-crystallographic data

13:10 - 15:00 Lunch Break and Poster Session II

13:20 - 14:40 Commercial Session (Room: Dendrite II/III)(Chair: Patrick Umbach)

13:20 - 13:50
Erhard Fernholz (Roche Biosciences, Penzberg, Germany)
Using Cell-Free Protein Expression Systems by Roche RTS-Technology

13:50 - 14:15
Dietrich Carlhoff (Amersham Biosciences, Uppsala, Sweden)
Automation of multidimensional protein chromatography

14:15 - 14:40
Günther Knebel (Greiner BioOne, Frickenhausen, Germany)
High Throughput Vapor Diffusion and Microbatch Protein Crystallization

15:00 - 15:40 Plenary Lecture (Chair: Wolfram Saenger)

Wayne A. Hendrickson (New York, USA)
Structural genomics of histidine kinase sensors

15:40 - 16:40 Bioinformatics: Functions (Chair: Chris Sander)

15:40 - 16:00
Olivier Lichtarge (Houston, TX, USA)
An accurate, scalable method to identify functional sites in protein structures

16:00 - 16:20
Kengo Kinoshita (Yokohama, Japan)
Analysis of complementarity of protein-DNA interactions using the molecular surface database, eF-site

16:20 - 16:40
Takanori Tanaka (Yokohama, Japan)
Characteristics and prediction of domain linker sequences in multi-domain proteins

16:40 - 17:10 Coffee Break

17:10 - 18:30 X-ray Methods for Structural Genomics (Chair: Tom C. Terwilliger)

17:10 - 17:30
Victor Lamzin (Hamburg, Germany)
ARP/wARP for automated modelling and refinement of protein crystal structures: the next generation

17:30 - 17:50
Tom Terwilliger (Los Alamos, NM, USA)
Automated structure solution, density modification, and model building for MAD, SAD and MIR

17:50 - 18:10
Wayne F. Anderson (Chicago, IL, USA)
Automating crystallographic structure determination

18:10 - 18:30
Dominika Borek (Dallas, TX, USA)
Phasing protocols for structural genomics

20:00 Conference Dinner

10:00 - 11:00 International Coordination for Structural Genomics (Chair: Tom C. Terwilliger)

10:00 - 10:20
Helen Berman (Piscataway, NJ, USA)
Enabling high-throughput data deposition to the Protein Data Bank

10:20 - 10:40
Mitch Guss (Sydney, Australia)
Facilitating publication of the results from structural genomics efforts

10:40 - 11:00
Tom Terwilliger (Los Alamos, NM, USA)
ISGO -- International cooperation in structural genomics

11:00 - 11:30 Coffee Break

11:30 - 12:10 Plenary Lecture (Chair: Klaus Peter Hofmann)

Shigeyuki Yokoyama (Yokohama, Japan)
Structural genomics and proteomics of genetic and cell signaling systems

12:10 - 13:10 Protein Production for Structural Genomics, continued (Chair: Shigeyuki Yokoyama)

12:10 - 12:30
Christine Lang (Berlin, Germany)
A micro-scale process for high-throughput expression of cDNAs in the yeast Saccharomyces cerevisiae

12:30 - 12:50
Alexei Savchenko (Toronto, Canada)
Strategies for rapid and efficient production of structural proteomics samples

12:50 - 13:10
Andrzej Joachimiak (Argonne, IL, USA)
Automation of protein purification for structural genomics

13:10 - 15:00 Lunch Break and Poster Session II

15:00 - 15:40 Plenary Lecture (Chair: Matthias Wilmanns)

Stephen K. Burley (San Diego, USA)
Structure-based drug discovery

15:40 - 16:40 Applications from Protein Structures (Chair: Wayne A. Hendrickson)

15:40 - 16:00
Yoonsang Cho (College Station, TX, USA)
Crystal structure of ATP phosphoribosyltransferase from Mycobacterium tuberculosis: a potential TB drug target

16:00 - 16:20
Chantal Abergel (Marseille, France)
In search for new anti-bacterial target genes: a comparative/structural genomics approach

16:20 - 16:40
Larissa Podust (Nashville, TN, USA)
Structural genomics of the cytochrome P450 superfamily from Streptomyces: applications for generating new antibiotics

16:40 Close of Conference